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False premise
YOUR LETTERSMay 16 2008

A hybrid arises from the fusion of chromosomal DNA from two different species of organism. An embryo arises from the fusion of a male and female gamete.

Since neither of the above happens during the proposed stem-cell research, it is scientifically inaccurate and grossly misleading to use incorrect nomenclature. As I understand it, human (we are also an animal species) DNA is inserted into an empty animal cell (cow or sheep). You therefore have neither a hybrid nor an embryo as a result. When articles which have appeared stating that the cell thus formed contains 99.9% human DNA and 0.1% animal DNA, the 0.1% will be mitochondrial DNA from the "empty" cell.

Using the term "hybrid embryo" therefore conjures up all sorts of horror stories by a misinformed media and those without a degree in biology. I presume that those MPs whose religious faith precludes them from accepting this scientific research, incorrectly named, will not wish to avail themselves of any future benefits it may bring to them and their offspring.

If certain religions wish to adopt the highest moral and ethical stand, then perhaps we should not have doctors, nurses, hospitals, medicines and antibiotics. If your God wills it, you will either recover or die without non-divine intervention. If the nomenclature is scientifically wrong, will any vote be therefore invalid?

Stewart Birks, Invergordon.


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Posted by: Cynicus, Scotland on 10:23pm Thu 15 May 08
If the nomenclature is scientifically wrong, will any vote be therefore invalid?
-Stewart Birks, Invergordon

Mr Birks who, presumably has a degree in biology, himself neglects to give the entity a name. Would the following be a grotesque product of the imagination: chimæra?
Posted by: Alistair, Edinburgh on 11:30pm Thu 15 May 08
What about hippogrif or centaur, Cynicus?

Posted by: ColinE, Dundee on 9:04am Fri 16 May 08
Well said Stewart Birks - as I have pointed out in previous postings, the religous bigots and other antagonists who want to obstruct scientific advances which would alleviate human pain and suffering have fundamentally flawed competence with the English language. As a result their utterances amount to no more than nonsense.
Posted by: Oskar Matzerath, Glasgow on 11:09am Fri 16 May 08
On the one side of this debate we have rational, cold scientific analysis. On the other we have a group with little specialist knowledge resorting to the use of terms such as 'Frankenstein', 'Chimera', 'Grotesque', 'Centaur' or 'Hippogrif'. Guess who wins?

Also, I love the arrogance of the suggestion that simply because a bunch of trough-snorting parliamentarians, subject to intense lobbying by special interest groups such as those espousing religiosity or pharmaceutical companies expressing 'humane concerns' (ie, a massive decline in profits once this great leap has been made ), make the practise of this science illegal that the knowledge will simply die.

Wrong. This is the next great step to be made in human development and whether politicians or pulpit ayatollahs like it or not this knowledge will be thoroughly researched, funded and perfected, be it here in the UK or abroad.

Think on this: Ten or fifteen years from now your loved one could be struck down with a horrific ailment for which there is no available cure on the NHS because of your high handed pontificating a decade earlier. Treatment is available however, for the cost of a house, and you have to go to Ukraine or Switzerland or China or Brunei or Singapore or some other more enlightened place. Will you sell your house to ease their suffering, or will you simply tell your child/spouse/parent/
sibling that to cure them would offend your ill-informed moral sensibility and as such their daily, hourly, permanent agony must continue?

Good for you if you say yes. There's nothing like other people's suffering to reassure the righteous.
Posted by: Gordon_J on 11:18am Fri 16 May 08
Well said Mr Birks.

I'm glad that someone is bringing some facts into the debate!
Posted by: Cynicus, Scotland on 4:16pm Fri 16 May 08
Alistair wrote:
What about hippogrif or centaur, Cynicus?

I think they are the sort of fictional creature that lead to the rhetorical definition of Chimæra: a grotesque product of the imagination.
But it also has a long established medical use which pre-dates this controversy.
Chimera: In medicine, a person composed of two genetically distinct types of cells Human chimeras were first discovered with the advent of blood typing when it was found that some people had more than one blood type
-Webster's New World Medical Dictionary. In genetics, a Chimera is typically defined as "an organism with genetically different tissues: an organism, or part of one, with at least two genetically different tissues resulting from mutation, the grafting of plants, or the insertion of foreign cells into an embryo"

If this term, routinely used by geneticists, is unacceptable to Alistair or Mr Birks' cheerleaders here, perhaps they will propose an alternative?
Posted by: ColinE, Dundee on 4:48pm Fri 16 May 08
Hey Cynacus - Webster's New World Medical Dictionary is FAR too advanced for you - just stick with a simple English dictionary - lots for you to learn there!
Posted by: Observer, Glasgow on 5:17pm Fri 16 May 08
I don't think it is a hybrid or a chimera. As the nucleus is removed from the cow's egg and in the process removes the genetic and species identity, the egg is essentially an empty shell - it is inter species, but not cross species.









Posted by: Observer, Glasgow on 5:19pm Fri 16 May 08
Alistair wrote:
What about hippogrif or centaur, Cynicus?
Minotaurs is more accurate.

The alternative is to name them after Dr Minger.

Let's stick to minotaurs.
Posted by: sam, greenock on 5:53pm Fri 16 May 08
Oskar Matzerath wrote:
On the one side of this debate we have rational, cold scientific analysis. On the other we have a group with little specialist knowledge resorting to the use of terms such as 'Frankenstein', 'Chimera', 'Grotesque', 'Centaur' or 'Hippogrif'. Guess who wins? Also, I love the arrogance of the suggestion that simply because a bunch of trough-snorting parliamentarians, subject to intense lobbying by special interest groups such as those espousing religiosity or pharmaceutical companies expressing 'humane concerns' (ie, a massive decline in profits once this great leap has been made ), make the practise of this science illegal that the knowledge will simply die. Wrong. This is the next great step to be made in human development and whether politicians or pulpit ayatollahs like it or not this knowledge will be thoroughly researched, funded and perfected, be it here in the UK or abroad. Think on this: Ten or fifteen years from now your loved one could be struck down with a horrific ailment for which there is no available cure on the NHS because of your high handed pontificating a decade earlier. Treatment is available however, for the cost of a house, and you have to go to Ukraine or Switzerland or China or Brunei or Singapore or some other more enlightened place. Will you sell your house to ease their suffering, or will you simply tell your child/spouse/parent/ sibling that to cure them would offend your ill-informed moral sensibility and as such their daily, hourly, permanent agony must continue? Good for you if you say yes. There's nothing like other people's suffering to reassure the righteous.
Well said.
Posted by: julie, glasgow on 6:17pm Fri 16 May 08
The strictly scientifically correct term for an embryo that is less than 14 days old is 'blastocyst'. I would not attribute any sinister motive to the use of the word 'embryo' however; those on both sides of this argument have used it and it is the term employed in the bill. The over-arching term used for all types of human-nonhuman combinations in the bill is 'ad-mixed embryo'.

It's worth pointing out that this bill does permit the creation of hybrid embryos as understood by Stewart; that is a 50:50 human/animal combination, although the ones being used for the moment are the de-nucleated egg ones.
I've put a list of terms that I found on the Cambridge Network Bio Science page; I don't know if they will help or hinder, but so much does depend on good definition in law and debate, that I think it's worth getting right. As for the rest of the argument, i'm bowing out; I've had my say on other posts on this subject. i'm against this bill if anyone wants to know, and I say that as someone who is looking after an Alzheimers sufferer. I've watched this debate for several months and it's clear to me that the only interest that anyone has in us is to use us as an excuse for their own commercial ends. Perhaps the most vital difference between adult stem cell treatments and embryonic stem cell treatments is that you can patent embryonic ones, but you can't patent adult ones and I think that is what lies at the bottom of this. Here are the definitions for anyone that's interested.


Cytoplasmic hybrids (also known as “cybrids”) are created by removing the nucleus of an animal egg cell (which stops it becoming an animal) and replacing it with one from a human (which helps it to become human).

True hybrids are created by combining human gametes (i.e. egg or sperm) with animal gametes.

Human transgenic embryos are created by introducing animal DNA into one or more cells of a human embryo. This encompasses both nuclear and mitochondrial DNA.

Human animal chimeras are created by adding animal cells to a human embryo. A chimera is an organism comprised of cells from two or more genetically different organisms. A mouse-mouse chimera might, for example, be made by adding stem cells from a sandy-coloured mouse to the developing embryo of a black mouse. The resulting mouse is perfectly normal, but remarkable in having two genomes. In this example, the chimeric mouse might have black and sandy fur.
Posted by: Brian D Finch, Brigadoon on 6:48pm Fri 16 May 08
ColinE, Dundee:
Hey Cynacus - Webster's New World Medical Dictionary is FAR too advanced for you - just stick with a simple English dictionary - lots for you to learn there
At least Cynicus can spell 'chimera' - and give evidence of knowing what it means. You can't even spell 'Cynicus'. Perhaps you should stick with the paper of record in Dundee (by which I mean the Beano ).
Posted by: Brian D Finch, Brigadoon on 6:51pm Fri 16 May 08
Thank you julie. Your posts are most informative - if a little challenging for some of the Beano readers above.
Posted by: Brian D Finch, Brigadoon on 7:03pm Fri 16 May 08
Thank you julie. Your posts are most informative - if a little challenging for some of the Beano readers above.
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